Nose Cancer and Nose Cancer Screening — Malaysia Patient Guide
DTAPclinic Editorial · Information only
Published · Cancer· Independent health education for Malaysia — not a clinic and not medical advice.
Overview
This independent guide from DTAPclinic covers clinic services and patient education for readers in Malaysia. Below we explain nose cancer and nose cancer screening — malaysia patient guide in accessible language. Content is for education only and is not medical advice, diagnosis, or a substitute for care from a registered provider.
Nose Cancer and Nose Cancer Screening
What is Nose Cancer (Nasopharyngeal carcinoma)?
Nasopharyngeal carcinoma (NPC) is a cancer that arises from the back of the nasal cavity. It is more common in Asia than in Western countries.
What are the Signs and Symptoms of Nose Cancer?
What to look out for? Common presenting complaints include: • Block nose • Headache • Double vision • Neck lumps and bumps • Nosebleed • Blood stained saliva • Hearing loss NPC can behave like a silent killer. One can be asymptomatic or showing no symptoms before experiencing symptoms . Over time, the tumour can grow, ulcerate and invade into nearby structures leading to nerve involvement and other symptoms as stated above. A tumour can also spread to distant spread to other parts of the body.
What are the risk factors for Nose Cancer?
Age and Gender It is a cancer that is more common in males. There is also a bimodal age presentation where occurrence peaks in younger and older adults. Infective Epstein – Barr virus (EBV) infection The strong association between EBV infection and NPC is evident by anti-EBV antibody in the blood, an increased amount of EBV DNA levels in NPC tumour cells. This is why EBV antibodies are used in the clinical setting for the screening of Nose cancer. Human Papillomavirus (HPV) infection The role of HPV in NPC is less clear-cut in comparison to EBV in NPC but studies have shown that there might be an association with Nose Cancer. Lifestyle Smoking There is postulation that smoking contributes to risks of NPC by causing reactivation of EBV. Even though there might not be sufficient evidence, smoking itself does cause many other diseases. Dietary practice Consuming preserved food which contains a high level of nitrosamines like salted fish, bacterial mutagens and EBV-reactivating substances is another risk of NPC. Some traditional Chinese medical herbs intake can lead to reactivation of EBV. Genetic Susceptibility NPC has been associated with certain genetic predisposition and risks of NPC is increased in patients with first-degree relatives with NPC.
Nose Cancer Screening
History and Physical Examination. A thin camera also known as a flexible naso-endoscopy is useful for examination of the back of the nasal cavity and if needed, a tissue biopsy sample to be obtained at the same setting. Future Tests include: Blood Tests A simple non-fasting screening blood test can be done to aid the detection of NPC. Given the close association between EBV and NPC, laboratory blood tests like EBV viral DNA and EBV IgA serology tests can be performed in the screening of NPC for patients belonging in high risks groups. Screening tests are recommended for patients who fall under the high risks group eg, those with positive family history. That said, studies have also shown that early NPC being an indolent killer due to its relatively asymptomatic nature, has a higher 5-year survival rate when detected at an early stage. (see reference below) In addition, these tests can help to prognosticate treatment response and future recurrence of the same disease in patients diagnosed with NPC. Radiological Other imaging studies include magnetic resonance imaging (MRI) might be useful.
Treatment for Nose Cancer
Treatment options include radiotherapy, chemotherapy and surgery. Combined therapy of radiotherapy and chemotherapy together with surgery might be considered based on the location and extent of the lesion. If you are interested in this service and wish to find out more, please call +65 6962 7144 or visit our clinic or drop us an email at hello@dtapclinic.com.sg. Reference: 1 ) Chan, K. C. A., Woo, J. K. S., King, A., Zee, B. C. Y., Lam, W. K. J., Chan, S. L., … Lo, Y. M. D. (2017). Analysis of Plasma Epstein–Barr Virus DNA to screen for nasopharyngeal cancer. New England Journal of Medicine,378 (10), 973-973. doi:10.1056/nejmx180004
Articles on this site are independently edited patient guides for Malaysia. They are rewritten for local readers, exclude clinic promotions, and must not be copied from other publishers.